Sponzilli E E, Smith J K, Malamud N, McCulloch J R
Neurology. 1975 Jul;25(7):664-8. doi: 10.1212/wnl.25.7.664.
Progressive multifocal leukoencephalopathy developed in a patient with rheumatoid arthritis after treatment with an immunosuppressive agent (chlorambucil). We fell that this case lends further support to the concept that an altered immunologic state is important in the appearance of this infection, which is probably viral in origin.
一名类风湿关节炎患者在接受免疫抑制剂（苯丁酸氮芥）治疗后发生了进行性多灶性白质脑病。我们认为该病例进一步支持了这样一种观点，即免疫状态改变在这种可能源于病毒的感染的发生中起重要作用。
