Importance of the TIMI frame count: implications for future trials.
作者信息
Appleby Mark A, Michaels Andrew D, Chen Michael, Michael C Gibson
机构信息
University of California at San Francisco Medical Center, San Francisco, California, USA.
出版信息
Curr Control Trials Cardiovasc Med. 2000;1(1):31-34. doi: 10.1186/cvm-1-1-031.
Abstract
Although the TIMI (Thrombolysis In Myocardial Infarction) flow grade classification scheme is widely used to assess angiographic outcomes, it is limited by poor reproducibility and its categoric nature. The corrected TIMI frame count (CTFC) is a simple, more objective continuous variable index of coronary blood flow that can be broadly and inexpensively applied. This measure of the time for dye to traverse a coronary artery is both accurate (highly correlated with Doppler velocity measurements) and precise (reproducible). The method has been prospectively validated as providing independent risk stratification above and beyond the conventional TIMI flow grades. It has been shown to be a predictor of restenosis, and has been of value in elucidating the underlying pathophysiology of acute myocardial infarction. In view of the above and its ease of use, we anticipate that CTFC will become a widely used method to evaluate coronary blood flow.
摘要
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