Nerrienet Eric, Meertens Laurent, Kfutwah Anfumbom, Foupouapouognigni Yacouba, Gessain Antoine
Centre Pasteur du Cameroun, BP 1274, Yaoundé, Cameroon1.
Unité d'Epidémiologie et Physiopathologie des Virus Oncogènes, Département du SIDA et des Rétrovirus, Institut Pasteur, 25-28 rue du Dr Roux, 75724 Paris Cedex 15, France2.
J Gen Virol. 2001 Dec;82(Pt 12):2973-2977. doi: 10.1099/0022-1317-82-12-2973.
A serological survey for human T-lymphotropic virus (HTLV)/simian T-lymphotropic virus (STLV) antibodies was performed in 102 wild-caught monkeys and apes from 15 (sub)species originating from Cameroon. Two animals (a Mandrillus sphinx and a Cercocebus agilis) exhibited a complete HTLV-1 seroreactivity pattern while two others lacked either the p24 (a Mandrillus sphinx) or the MTA-1/gp46 bands (a Pan troglodytes). Sequence comparison and phylogenetic analyses, using a 522 bp env gene fragment and the complete LTR, indicated that the two mandrill STLV strains belonged to the HTLV/STLV subtype D clade while the chimpanzee strain clustered in the HTLV/STLV subtype B clade. The Cercocebus agilis STLV strain, the first one found in this species, was closely related to the two HTLV/STLV subtype F strains. Such data indicate that the African biodiversity of STLV-1 in the wild is far from being known and reinforces the hypothesis of interspecies transmission of STLV-1 from monkeys and apes to humans leading to the present day distribution of HTLV-1 in African inhabitants.
对来自喀麦隆的15个（亚）种的102只野生捕获的猴子和猿类进行了人类嗜T淋巴细胞病毒（HTLV）/猴嗜T淋巴细胞病毒（STLV）抗体的血清学调查。两只动物（一只白臀长尾猴和一只敏捷长尾猴）呈现出完整的HTLV-1血清反应模式，而另外两只则缺少p24（一只白臀长尾猴）或MTA-1/gp46条带（一只黑猩猩）。使用522 bp的env基因片段和完整的长末端重复序列（LTR）进行序列比较和系统发育分析表明，两只山魈STLV毒株属于HTLV/STLV D亚型分支，而黑猩猩毒株聚集在HTLV/STLV B亚型分支中。敏捷长尾猴的STLV毒株是在该物种中发现的第一个毒株，与两个HTLV/STLV F亚型毒株密切相关。这些数据表明，野生STLV-1在非洲的生物多样性远未为人所知，并强化了STLV-1从猴子和猿类跨物种传播给人类从而导致当今HTLV-1在非洲居民中分布的假说。
