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[骨髓增生异常综合征中的急性全身性猫抓病]

[Acute generalized cat scratch disease in myelodysplastic syndrome].

作者信息

von Kobyletzki G, Nordmeier R, Stücker M, Sandmann M, Respondek M, Baier J, Altmeyer P

机构信息

St. Josef Hospital, Dermatologische Klinik der Ruhr-Universität Bochum.

出版信息

Hautarzt. 2001 Oct;52(10 Pt 2):980-4.

Abstract

In patients with normal immunity, cat scratch disease typically develop a papule at the portal of entry and no other cutaneous features. A 73 year old male patient with a myelodysplastic syndrome developed generalized petechial, papular and, vasculitic skin lesions in association with cat scratch disease. After the diagnosis was established by identifying the causative organism in a lymph node biopsy, the patient was treated with erythromycin for three weeks resulting in progressive clearance of the skin lesions. Apart from the soluble IL-2 receptor, no other serologic inflammatory parameters were elevated. IgG antibodies against Bartonella henselae and Bartonella quintana increased only slightly during acute exacerbation of the disease, but significantly increased some months later. The diagnosis was established by the positive staining of the lymph node biopsy using the Warthin-Starry stain.

摘要

在免疫功能正常的患者中,猫抓病通常在感染入口处出现丘疹,无其他皮肤表现。一名73岁患有骨髓增生异常综合征的男性患者,在患猫抓病时出现了全身性瘀点、丘疹和血管炎性皮肤病变。通过在淋巴结活检中鉴定出病原体确诊后,该患者接受了三周的红霉素治疗,皮肤病变逐渐消退。除可溶性白细胞介素-2受体外,没有其他血清学炎症参数升高。抗汉赛巴尔通体和五日热巴尔通体的IgG抗体在疾病急性加重期仅略有增加,但数月后显著增加。通过使用Warthin-Starry染色对淋巴结活检进行阳性染色确诊。

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