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[皮肤血管炎揭示猫抓病]

[Cutaneous vasculitis disclosing cat-scratch disease].

作者信息

Schmoor P, Darie H, Maccari F, Gros P, Millet P

机构信息

Service de Dermatologie, Hôpital d'Instruction des Armées Bégin, Saint-Mandé.

出版信息

Ann Dermatol Venereol. 1998 Dec;125(12):894-6.

PMID:9922863
Abstract

BACKGROUND

We describe a case of cat-scratch disease ingnaugurated by vascular purpura and discuss the role of the causal agent, Bartonella henselae.

CASE REPORT

A 49-year-old woman presented vascular purpura without fever. Skin biopsy demonstrated leukocytoclasic vasculitis. She owned a cat and a had a scratch scar on the back of her left hand. A few days later, two inflammatory epitrochlear lymph nodes suppurated. Catscratch disease was confirmed by serology and PRC analysis of pus aspirated from the nodes. The purpura resolved spontaneously in three weeks. Left axillary adenopathy developed and suppurated. In spite of four antibiotics, the nodes subsided only ten months later, leaving scars.

DISCUSSION

Two arguments favor Bartonella henselae as the causal agent in this cutaneous vasculitis. The simultaneous onset of the two diseases and the absence of another cause of vasculitis. This patient did not have Bartonella henselae endocarditis which could have explained this vasculitis. Only one case of hypersensitivity vasculitis has been described during cat-scratch disease. The exceptional feature of this association is perhaps the result of the unawareness of moderate or asymptomatic cat-scratch disease. Bartonella henselae was possibility caused hypersensitivity vasculitis.

摘要

背景

我们描述了一例以血管性紫癜为首发症状的猫抓病病例,并讨论了病原体汉赛巴尔通体的作用。

病例报告

一名49岁女性出现无发热的血管性紫癜。皮肤活检显示白细胞破碎性血管炎。她养了一只猫,左手背有一处抓伤疤痕。几天后,两个炎性滑车上淋巴结化脓。通过血清学检查以及对从淋巴结抽取的脓液进行聚合酶链反应分析,确诊为猫抓病。紫癜在三周内自行消退。左腋窝淋巴结病出现并化脓。尽管使用了四种抗生素,这些淋巴结直到十个月后才消退,留下了疤痕。

讨论

有两个论据支持汉赛巴尔通体是这种皮肤血管炎的病原体。两种疾病同时出现且不存在血管炎的其他病因。该患者没有可解释这种血管炎的汉赛巴尔通体心内膜炎。在猫抓病期间仅描述过一例超敏性血管炎。这种关联的特殊之处可能是由于对中度或无症状猫抓病认识不足所致。汉赛巴尔通体可能引发了超敏性血管炎。

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