妊娠期宫颈发育异常：产后进展与消退情况

Cervical dysplasia in pregnancy: progression versus regression post-partum.

作者信息

Siddiqui G, Kurzel R B, Lampley E C, Kang H S, Blankstein J

机构信息

Department of Obstetrics and Gynecology, Mount Sinai Hospital Medical Center, Chicago, Illinois, USA.

出版信息

Int J Fertil Womens Med. 2001 Sep-Oct;46(5):278-80.

PMID:11720201

Abstract

OBJECTIVE

To assess the natural history of cervical dysplasia during pregnancy and determine the rates for progression or regression post-partum by the severity of the lesion.

METHOD

This was a retrospective study of 100 patients screened by PAP smear. Lesions were graded by colposcopy and biopsy, and followed post-partum.

RESULTS

Lesions were graded as ASCUS, LGSIL, and HGSIL. The majority of lesions showed a tendency to regress post-partum (approximately 64%), a trend that was statistically significant (P < .003). A substantial minority (approximately 34%) showed no change in severity of the lesion. The tendency for lesions to progress in severity was very low (approximately 3%). No patient had microinvasive disease. Of patients who had CIS, persistence of this lesion post-partum was present in 67%.

CONCLUSION

Patients with cervical dysplasia in pregnancy may be followed conservatively with colposcopy and biopsy.

摘要

目的

评估妊娠期宫颈发育异常的自然病史，并根据病变严重程度确定产后进展或消退的发生率。

方法

这是一项对100例经巴氏涂片筛查患者的回顾性研究。病变通过阴道镜检查和活检进行分级，并在产后进行随访。

结果

病变分为非典型鳞状细胞不能明确意义（ASCUS）、低度鳞状上皮内病变（LGSIL）和高度鳞状上皮内病变（HGSIL）。大多数病变在产后有消退趋势（约64%），这一趋势具有统计学意义（P < .003）。相当少数（约34%）的病变严重程度无变化。病变严重程度进展的趋势非常低（约3%）。没有患者患有微浸润性疾病。患有原位癌（CIS）的患者中，产后该病变持续存在的比例为67%。