Fischer U, Hommel H, Schmid E
Pflugers Arch. 1975 Jul 9;358(1):89-100. doi: 10.1007/BF00584572.
Blood flow through the superior pancreaticoduodenal artery of anaesthetized dogs increases immediately after an i.v. glucose load and parallels to glycemia, but not to insulin output. Flow of superior mesenteric, and femoral arteries as well as of portal vein are also enhanced after rapid i.v. injections of glucose or mannitol. Extent and duration of all flow increases are dose-dependent and strongly related to the alterations of arterial plasma osmolality (maximum increase 24 mosmoles/kg). Heart rate, mean arterial blood pressure, and hematocrit remain unchanged after the first test minute. There is a considerable decrease of peripheral vascular resistance in the circulatory regions investigated. Flow through aorta ascendens is augmented for a short time. Possible mechanisms of vasodilatation are reflexes produced by osmoreceptors and/or local effects of osmolality on the tonus of vascular muscle. Within the physiological range pancreatic perfusion does not determine the amount of insulin released.
麻醉犬静脉注射葡萄糖负荷后，通过胰十二指肠上动脉的血流量立即增加，并与血糖平行，但与胰岛素分泌量无关。快速静脉注射葡萄糖或甘露醇后，肠系膜上动脉、股动脉以及门静脉的血流量也会增加。所有血流量增加的程度和持续时间均呈剂量依赖性，且与动脉血浆渗透压的变化密切相关（最大增加24毫渗摩尔/千克）。在第一个测试分钟后，心率、平均动脉血压和血细胞比容保持不变。在所研究的循环区域中，外周血管阻力显著降低。升主动脉的血流量在短时间内增加。血管舒张的可能机制是由渗透压感受器产生的反射和/或渗透压对血管平滑肌张力的局部作用。在生理范围内，胰腺灌注并不决定胰岛素的释放量。
