Nagaretani H, Nakamura T, Funahashi T, Kotani K, Miyanaga M, Tokunaga K, Takahashi M, Nishizawa H, Kishida K, Kuriyama H, Hotta K, Yamashita S, Matsuzawa Y
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan.
Diabetes Care. 2001 Dec;24(12):2127-33. doi: 10.2337/diacare.24.12.2127.
The significance of abdominal visceral fat accumulation was evaluated in Japanese men with impaired glucose tolerance (IGT).
The IGT subjects (n = 123) were aged 55 +/- 9 years with a BMI of 24 +/- 3 kg/m(2). The 148 control subjects with normal glucose tolerance (NGT) were matched for age and BMI. IGT and NGT were classified according to the 1985 World Health Organization criteria. Abdominal fat distribution was analyzed by computed tomography at umbilical level. Plasma lipid, glucose, and insulin concentrations and blood pressure (BP) were measured.
In subjects with IGT, the average visceral fat area (VFA) was significantly greater than in subjects with NGT. Fasting insulin, the sum of insulin concentrations during an oral glucose tolerance test, insulin resistance according to a homeostasis model assessment for insulin resistance (HOMA-IR), systolic BP, and serum triglyceride were significantly higher, whereas the DeltaI(30-0)/DeltaG(30-0) was significantly lower, in subjects with IGT. Subjects with IGT and NGT were then divided into three subgroups according to the number of risk factors they possessed (dyslipidemia, hypertension, neither, or both). In both IGT and NGT subjects, BMI, VFA, subcutaneous fat area, fasting insulin, HOMA-IR, and insulin secretion of the homeostasis model assessment were significantly higher in the double-risk factor subgroup than in the no-risk factor subgroup, and VFA was a potent and independent variable in association with the presence of a double risk factor.
Visceral fat accumulation is a major contributor for multiple risk factor clustering in Japanese men with IGT and NGT.
评估日本糖耐量受损（IGT）男性腹部内脏脂肪堆积的意义。
IGT受试者（n = 123）年龄为55±9岁，体重指数（BMI）为24±3 kg/m²。148名糖耐量正常（NGT）的对照受试者按年龄和BMI进行匹配。IGT和NGT根据1985年世界卫生组织标准分类。通过脐水平计算机断层扫描分析腹部脂肪分布。测量血浆脂质、葡萄糖和胰岛素浓度以及血压（BP）。
在IGT受试者中，平均内脏脂肪面积（VFA）显著大于NGT受试者。IGT受试者的空腹胰岛素、口服葡萄糖耐量试验期间胰岛素浓度总和、根据胰岛素抵抗稳态模型评估（HOMA-IR）得出的胰岛素抵抗、收缩压和血清甘油三酯显著更高，而IGT受试者的ΔI(30 - 0)/ΔG(30 - 0)显著更低。然后根据IGT和NGT受试者所拥有的风险因素数量（血脂异常、高血压、无或两者皆有）将其分为三个亚组。在IGT和NGT受试者中，双风险因素亚组的BMI、VFA、皮下脂肪面积、空腹胰岛素、HOMA-IR和稳态模型评估的胰岛素分泌均显著高于无风险因素亚组，且VFA是与双风险因素存在相关的一个有力且独立的变量。
内脏脂肪堆积是日本IGT和NGT男性多种风险因素聚集的主要促成因素。
