Boné B K, Szabó B, Palkó A, Aspelin P
Karolinska Intézet, Huddinge Egyetemi Kórház, Radiológiai Osztály, Stockholm, Svédország.
Orv Hetil. 2001 Sep 30;142(39):2123-31.
Authors report about the role of contrast medium enhanced magnetic resonance imaging in diagnosis of breast diseases, and experiences with this method. The aim of the study was to determine the diagnostic accuracy of the method. The results was correlated with the histopathological findings, and compared to the diagnostic accuracy of the conventional X-ray mammography in breast lesions. X-ray and MR-mammography were evaluated in 220 patients (238 breasts) scheduled for breast surgery. The breasts were examined with T1-weighted transversal images using contrast medium enhanced semidynamic technique with 3D fast low angle shot (FLASH) sequence. Each breast was given a routine examination with 3 mammographic views. Contrast enhanced MR-mammography is a highly sensitive method for the detection of breast cancer, it has a higher diagnostic accuracy (84.5%), than conventional X-ray mammography (82.4%). When MRI and conventional X-ray mammography were used together, very high sensitivity but a lower diagnostic accuracy (81.5%) was achieved. MRI was effective in revealing mammographically equivocal or occult lesions and multifocal tumors even in dense breasts, but it was less reliable for some invasive lobular cancers, non-invasive ductal carcinomas, fibroadenomas and hyperplastic breast changes. Presently accepted indications for MRI of the breast are: (1) patients with breast implants--to demonstrate prothesis complications and tumor relapses; (2) postoperative imaging in patients after tumorectomy and radiation therapy--in these cases MRI allows differentiation between tumor relapses and extensive scars; (3) proven axillary lymph node metastasis from an unknown primary carcinoma; (4) preoperative MR imaging in cases suspected or verified carcinomas within dense breasts to exclude multicentricity/multifocality; (5) follow-up in chemotherapy of breast cancer; (6) patients with high-risk constellation.
作者报告了对比剂增强磁共振成像在乳腺疾病诊断中的作用以及该方法的应用经验。本研究的目的是确定该方法的诊断准确性。将结果与组织病理学结果进行关联,并与传统乳腺X线摄影在乳腺病变中的诊断准确性进行比较。对220例计划进行乳腺手术的患者(238个乳房)进行了X线和磁共振乳腺成像评估。使用对比剂增强半动态技术和三维快速低角度激发(FLASH)序列,对乳房进行T1加权横断面成像检查。每个乳房均进行常规的乳腺X线三个投照位检查。对比剂增强磁共振乳腺成像对乳腺癌的检测是一种高度敏感的方法,其诊断准确性(84.5%)高于传统乳腺X线摄影(82.4%)。当磁共振成像和传统乳腺X线摄影联合使用时,敏感性非常高,但诊断准确性较低(81.5%)。磁共振成像对于显示乳腺X线摄影难以明确或隐匿的病变以及多灶性肿瘤有效,即使在致密型乳腺中也是如此,但对于某些浸润性小叶癌、非浸润性导管癌、纤维腺瘤和乳腺增生性改变,其可靠性较低。目前公认的乳腺磁共振成像适应证为:(1)乳房植入物患者——用于显示假体并发症和肿瘤复发;(2)肿瘤切除术后及放疗后的患者进行术后成像——在这些情况下,磁共振成像可区分肿瘤复发和广泛的瘢痕;(3)已证实腋窝淋巴结转移但原发癌不明的患者;(4)怀疑或证实致密型乳腺内有癌的病例进行术前磁共振成像,以排除多中心性/多灶性;(5)乳腺癌化疗的随访;(6)具有高危因素的患者。