Zhang X, Amemo K, Ameno S, Iwahashi K, Kinoshita H, Kubota T, Mostofa J, Ijiri I
Department of Forensic Medicine, Kagawa Medical University, 1750-1, Ikenobe, Miki, Kita, Kagawa 761-0793, Japan.
Nihon Arukoru Yakubutsu Igakkai Zasshi. 2001 Oct;36(5):486-90.
This study determined the genotypes of the CYP2A6 gene in 96 smokers and 141 non-smokers in a Japanese population. The frequencies of wild-type of the CYP2A6* 1 and those with a whole deletion of the CYP2A6 gene were 93 (96.9%) and 3 (3.1%) in 96 smokers, and 134 (95.0%) and 7 (5.0%) in non-smokers, respectively. In addition, neither the CYP2A6* 2 nor CYP2A6* 3 alleles were observed in the population studied. There were no significant differences in the CYP2A6 genotype frequencies between smokers and non-smokers, as well as in the number of cigarettes smoked and the nicotine amounts inhaled per day between the CYP2A6* 1 and the deletion of CYP2A6. These results suggest that either the deletion or non-deletion of the CYP2A6 gene shows no significant effect on smoking behavior for the Japanese population examined.
本研究确定了日本人群中96名吸烟者和141名非吸烟者的CYP2A6基因的基因型。在96名吸烟者中，CYP2A61野生型和CYP2A6基因完全缺失者的频率分别为93（96.9%）和3（3.1%）；在非吸烟者中，分别为134（95.0%）和7（5.0%）。此外，在所研究的人群中未观察到CYP2A62和CYP2A63等位基因。吸烟者和非吸烟者之间的CYP2A6基因型频率，以及CYP2A61与CYP2A6缺失者之间每天吸烟支数和吸入尼古丁量均无显著差异。这些结果表明，CYP2A6基因的缺失或未缺失对所检测的日本人群的吸烟行为均无显著影响。
