Balog J A, Kurunczi A, Párducz A A
Molecular Neurobiology Laboratory, Institute of Biophysics, Biological Research Center, 6701 Szeged, P.O. Box 521, Hungary.
Neuroreport. 2001 Dec 4;12(17):3787-90. doi: 10.1097/00001756-200112040-00037.
In the present paper we investigated the c-Fos immunoreactivity in the accessory olfactory bulb (AOB) of juvenile, adult and old rats of both sexes, as well as the effect of 17beta-estradiol on the expression of this immediate early gene. Basal c-Fos expression in the olfactory bulb decreased with age, and estrogen treatment caused an increase in the number of neurons expressing c-Fos in the AOB. The results indicate that both aging and estrogen have roles in the ability of neurons to co-ordinate genetic activity. Our observations may explain the decrease in age-related changes of brain plasticity, and provide data for the understanding of hormonally regulated neuronal plasticity.
在本论文中，我们研究了幼年、成年和老年雄性及雌性大鼠副嗅球（AOB）中c-Fos免疫反应性，以及17β-雌二醇对这种即刻早期基因表达的影响。嗅球中基础c-Fos表达随年龄增长而降低，雌激素处理导致AOB中表达c-Fos的神经元数量增加。结果表明，衰老和雌激素在神经元协调基因活动的能力方面均发挥作用。我们的观察结果可能解释了与年龄相关的脑可塑性变化的减少，并为理解激素调节的神经元可塑性提供数据。
