McLellan R A, Wilkinson M, Brown R E
Department of Psychology, Dalhousie University, Halifax, Nova Scotia, Canada.
Neuroreport. 1998 Dec 1;9(17):3919-24. doi: 10.1097/00001756-199812010-00028.
The odours of adult males, which accelerate the timing of puberty of female mice, activate c-fos in the accessory olfactory bulb (AOB). To test the hypothesis that NMDA receptors are involved in the male odour-induced increase in c-fos expression, we studied the effects of the non-competitive NMDA receptor agonist MK-801 on male odour-induced c-fos expression in the AOB of juvenile female mice. Surprisingly, MK-801 increased FOS-like immunoreactivity (FLI) within the AOB in the absence of male odour and had no effect on male odour-induced c-fos expression. We suggest that MK-801 increases AOB mitral cell activity by disinhibiting GABAergic granule cells, resulting in increased c-fos expression throughout the AOB.
成年雄性的气味会加速雌性小鼠的青春期到来，这种气味会激活副嗅球（AOB）中的c-fos。为了验证NMDA受体参与雄性气味诱导的c-fos表达增加这一假说，我们研究了非竞争性NMDA受体激动剂MK-801对幼年雌性小鼠AOB中雄性气味诱导的c-fos表达的影响。令人惊讶的是，在没有雄性气味的情况下，MK-801增加了AOB内的FOS样免疫反应性（FLI），并且对雄性气味诱导的c-fos表达没有影响。我们认为，MK-801通过解除对GABA能颗粒细胞的抑制来增加AOB二尖瓣细胞的活性，从而导致整个AOB中c-fos表达增加。
