Harder A, von Samson-Himmelstjerna G
Business Group Animal Health, Research and Development, Biological Chemical Evaluation, Bayer AG, Monheim, Germany.
Parasitol Res. 2001 Nov;87(11):924-8. doi: 10.1007/s004360100479.
The present investigations deal with the activity of the cyclic depsipeptide emodepside (BAY 44-4400) against larval and adult stages of three rodent nematodes. While emodepside acts strongly against the adult stages of the rat nematodes Nippostrongylus brasiliensis and Strongyloides ratti, as well as against the mouse nematode Heligmosomoides polygyrus, its actions against the larval stages of these nematodes vary according to the species. Thus, emodepside is highly effective against the lung and intestine larval stages of N. brasiliensis and S. ratti. By contrast. the larval stages of H. polygyrus in the intestine are only partly affected by higher emodepside dosages.
目前的研究涉及环缩肽埃莫昔班（BAY 44 - 4400）对三种啮齿动物线虫幼虫和成虫阶段的活性。埃莫昔班对大鼠线虫巴西日圆线虫和鼠类圆线虫的成虫阶段以及小鼠线虫多房棘球绦虫有很强的作用，但其对这些线虫幼虫阶段的作用因物种而异。因此，埃莫昔班对巴西日圆线虫和鼠类圆线虫的肺和肠道幼虫阶段非常有效。相比之下，较高剂量的埃莫昔班仅部分影响多房棘球绦虫肠道中的幼虫阶段。
