Abe T, Sugaya H, Yoshimura K
Department of Parasitology, Akita University School of Medicine, Japan.
Parasite Immunol. 1993 Nov;15(11):643-5. doi: 10.1111/j.1365-3024.1993.tb00578.x.
Repetitive administration of recombinant IL-3 induced protection against Strongyloides ratti but not against Nippostrongylus brasiliensis in C57BL/6 mice. Numbers of S. ratti were negligible from day 4 to day 6 post-infection in mice injected with IL-3, whereas N. brasiliensis burdens were almost equal from day 4 to day 6 between mice injected with IL-3 or with medium. Mice treated with IL-3 and then concurrently infected with S. ratti and N. brasiliensis were protected from intestinal S. ratti but not from N. brasiliensis. The numbers of intestinal mucosal mast cells were increased by the repetitive IL-3 treatment on one day after the final injection and was augmented by subsequent infection with both nematodes.
在C57BL/6小鼠中，重复给予重组白细胞介素-3可诱导对鼠类圆线虫的保护作用，但对巴西日圆线虫无保护作用。在感染后第4天至第6天，注射白细胞介素-3的小鼠体内鼠类圆线虫的数量可忽略不计，而在第4天至第6天，注射白细胞介素-3或培养基的小鼠体内巴西日圆线虫的负荷几乎相等。用白细胞介素-3处理后同时感染鼠类圆线虫和巴西日圆线虫的小鼠，对肠道内的鼠类圆线虫有保护作用，但对巴西日圆线虫无保护作用。在最后一次注射后一天，重复的白细胞介素-3处理使肠道黏膜肥大细胞的数量增加，随后两种线虫的感染进一步增加了肥大细胞数量。
