Aronow W S, Frishman W H, Cheng-Lai A
Department of Geriatrics and Adult Development, Mt. Sinai Medical School, New York, NY, USA.
Heart Dis. 2000 Mar-Apr;2(2):151-67.
Cardiovascular diseases of various etiologies are most prevalent in the elderly, and there are many pharmacologic issues that need to be considered when prescribing drug therapies to this population. Aging itself alters the absorption, distribution, metabolism, and excretion of many drugs. Certain drugs, such as digoxin, lidocaine, and warfarin, need to be used with great caution in older patients because of a greater potential for drug toxicity. Elderly patients often are prescribed multiple drugs for different conditions, making them susceptible to major drug-drug interactions. Recommendations are provided to help ensure safe prescribing practices of cardiac drugs in older patients.
各种病因的心血管疾病在老年人中最为普遍，在给这一人群开药物治疗处方时，有许多药理学问题需要考虑。衰老本身会改变许多药物的吸收、分布、代谢和排泄。某些药物，如地高辛、利多卡因和华法林，由于药物毒性的可能性更大，在老年患者中使用时需要格外谨慎。老年患者常常因不同病症而被开多种药物，这使他们容易发生严重的药物相互作用。现提供相关建议，以帮助确保老年患者心脏药物的安全处方做法。
