Kuperman S, Schlosser S S, Kramer J R, Bucholz K, Hesselbrock V, Reich T, Reich W
Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, IA 52242-1047, USA.
Am J Psychiatry. 2001 Dec;158(12):2022-6. doi: 10.1176/appi.ajp.158.12.2022.
The authors sought to clinically describe the relationship of disruptive behavior disorders with both alcohol dependence and the use of a variety of substances.
The Child Semi-Structured Assessment for the Genetics of Alcoholism was used to collect data on 54 adolescents with a diagnosis of alcohol dependence. The frequency and age at onset of the disruptive behavior disorder diagnoses were examined as well as age at first use of alcohol, tobacco, marijuana, and other street drugs.
Nearly three-quarters of the alcohol-dependent adolescents had at least one disruptive behavior disorder diagnosis. Attention deficit hyperactivity disorder (ADHD) typically occurred first, followed by conduct disorder. Substance use began with alcohol or tobacco, followed by marijuana and then other street drugs. Alcohol dependence began significantly later than the onset of either ADHD or conduct disorder and significantly later than the first use of tobacco.
Disruptive behavior diagnoses, particularly conduct disorder, typically precede the initiation of use of a variety of substances that, in turn, precede the diagnosis of alcohol dependence in adolescents.
作者试图从临床角度描述破坏性行为障碍与酒精依赖以及多种物质使用之间的关系。
采用酒精中毒遗传学儿童半结构化评估法收集54名诊断为酒精依赖的青少年的数据。研究了破坏性行为障碍诊断的频率和发病年龄，以及首次使用酒精、烟草、大麻和其他街头毒品的年龄。
近四分之三酒精依赖青少年至少有一项破坏性行为障碍诊断。注意缺陷多动障碍（ADHD）通常最先出现，其次是品行障碍。物质使用始于酒精或烟草，其次是大麻，然后是其他街头毒品。酒精依赖开始的时间明显晚于ADHD或品行障碍的发病时间，且明显晚于首次使用烟草的时间。
破坏性行为诊断，尤其是品行障碍，通常先于青少年开始使用多种物质，而这些物质的使用又先于酒精依赖的诊断。
