Population admixture may appear to mask, change or reverse genetic effects of genes underlying complex traits.
作者信息
Deng H W
机构信息
Laboratory of Molecular and Statistical Genetics, College of Life Sciences, Hunan Normal University, ChangSha, Hunan 410081, People's Republic of China.
出版信息
Genetics. 2001 Nov;159(3):1319-23. doi: 10.1093/genetics/159.3.1319.
Abstract
Association studies using random population samples are increasingly being applied in the identification and inference of genetic effects of genes underlying complex traits. It is well recognized that population admixture may yield false-positive identification of genetic effects for complex traits. However, it is less well appreciated that population admixture can appear to mask, change, or reverse true genetic effects for genes underlying complex traits. By employing a simple population genetics model, we explore the effects and the conditions of population admixture in masking, changing, or even reversing true genetic effects of genes underlying complex traits.
摘要
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本文引用的文献
1
Population admixture: detection by Hardy-Weinberg test and its quantitative effects on linkage-disequilibrium methods for localizing genes underlying complex traits.
Genetics. 2001 Feb;157(2):885-97. doi: 10.1093/genetics/157.2.885.
2
Genetic determination of Colles' fracture and differential bone mass in women with and without Colles' fracture.
J Bone Miner Res. 2000 Jul;15(7):1243-52. doi: 10.1359/jbmr.2000.15.7.1243.
3
QTL fine mapping, in extreme samples of finite populations, for complex traits with familial correlation due to polygenes.
Am J Hum Genet. 2000 Jul;67(1):259-62. doi: 10.1086/302977.
4
QTL fine mapping by measuring and testing for Hardy-Weinberg and linkage disequilibrium at a series of linked marker loci in extreme samples of populations.
Am J Hum Genet. 2000 Mar;66(3):1027-45. doi: 10.1086/302804.
5
Re: "Biased tests of association: comparisons of allele frequencies when departing from Hardy-Weinberg proportions".
Am J Epidemiol. 2000 Feb 1;151(3):335-7. doi: 10.1093/oxfordjournals.aje.a010210.
6
Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: different conclusions with different analyses and the implications.
Osteoporos Int. 1999;9(6):499-507. doi: 10.1007/s001980050177.
7
The association of bone mineral density with vitamin D receptor gene polymorphisms.
Osteoporos Int. 1999;9(1):55-64. doi: 10.1007/s001980050116.
8
The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases I. DNA pooling.
Genome Res. 1998 Dec;8(12):1273-88. doi: 10.1101/gr.8.12.1273.
9
Tests and estimates of allelic association in complex inheritance.
Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11389-93. doi: 10.1073/pnas.95.19.11389.
10
Transmission-disequilibrium tests for quantitative traits.
Am J Hum Genet. 1997 Mar;60(3):676-90.
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