Memelink J, Kijne J W, van der Heijden R, Verpoorte R
Institute of Molecular Plant Sciences, Clusius Laboratory, Wassenaarseweg 64, 2333 AL Leiden, The Netherlands.
Adv Biochem Eng Biotechnol. 2001;72:103-25. doi: 10.1007/3-540-45302-4_4.
Plant secondary metabolism is the source of many natural products with diverse applications, including pharmaceuticals, food colors, dyes and fragrances. Functions in plants include attraction of pollinating insects and protection against pests and pathogens. An important regulatory step in secondary metabolism is transcription of the biosynthetic genes. The aim of this chapter is to discuss results and opportunities concerning modification of secondary metabolism using transcriptional regulators. The transcriptional regulation of two well-studied secondary pathways, the phenylpropanoid pathway and its flavonoid branch, and the terpenoid indole alkaloid biosynthetic pathway, are reviewed. Some examples of successful engineering of these pathways via transcriptional regulators are discussed.
植物次生代谢是许多具有多种用途的天然产物的来源，这些用途包括制药、食用色素、染料和香料。在植物中的功能包括吸引传粉昆虫以及抵御害虫和病原体。次生代谢中的一个重要调控步骤是生物合成基因的转录。本章的目的是讨论有关使用转录调节因子修饰次生代谢的结果和机会。综述了两个研究充分的次生途径，即苯丙烷途径及其类黄酮分支，以及萜类吲哚生物碱生物合成途径的转录调控。还讨论了通过转录调节因子成功改造这些途径的一些例子。
