Newton R W
JAMA. 1975 Mar 3;231(9):941-3.
Following intravenous administration of physostigmine salicylate for tricyclic antidepressant poisoning in 21 patients, convulsions occurred in two patients, and severe cholinergic manifestations occurred in two others. Because of these untoward effects and the very short duration of its beneficial action, it is very doubtful that physostigmine has any place in the routine management of tricyclic antidepressant poisoning.
对21例三环类抗抑郁药中毒患者静脉注射水杨酸毒扁豆碱后，有2例发生惊厥，另有2例出现严重的胆碱能表现。由于这些不良反应以及其有益作用的持续时间非常短，水杨酸毒扁豆碱在三环类抗抑郁药中毒的常规治疗中是否有任何地位非常值得怀疑。
