Shawn D H, McGuigan M A
Can Med Assoc J. 1984 Jun 1;130(11):1460-1.
Two cases in which dermal absorption of promethazine hydrochloride resulted in a toxic neurologic syndrome are reported. The symptoms included central nervous system depression, acute excitomotor manifestations, ataxia and visual hallucinations. In addition, peripheral anticholinergic effects occurred. These symptoms are comparable with those of oral, intramuscular and rectal overdose of promethazine. The demonstrated risks of the topical use of promethazine outweigh any benefits.
报告了两例盐酸异丙嗪经皮肤吸收导致中毒性神经综合征的病例。症状包括中枢神经系统抑制、急性兴奋运动表现、共济失调和视幻觉。此外，还出现了外周抗胆碱能作用。这些症状与口服、肌肉注射和直肠过量使用异丙嗪的症状相似。已证明的异丙嗪局部使用风险超过了任何益处。
