螺旋藻对环磷酰胺和丝裂霉素-C诱导的小鼠遗传毒性和氧化应激的影响。

Effect of Spirulina fusiformis on cyclophosphamide and mitomycin-C induced genotoxicity and oxidative stress in mice.

作者信息

Premkumar K, Pachiappan A, Abraham S K, Santhiya S T, Gopinath P M, Ramesh A

机构信息

Department of Genetics, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600-113, India.

出版信息

Fitoterapia. 2001 Dec;72(8):906-11. doi: 10.1016/s0367-326x(01)00340-9.

DOI:10.1016/s0367-326x(01)00340-9

PMID:11731115

Abstract

Spirulina fusiformis was tested for its possible in vivo protective effects against cyclophosphamide (CP) and mitomycin-C (MMC) induced genotoxicity and oxidative stress in mice. Pre-treatment with S. fusiformis (250, 500 and 1000 mg kg(-1), p.o., daily for 5 days) significantly reduced the chromosomal damage and lipid peroxidation with concomitant changes in antioxidants and detoxification systems. All the three tested doses were effective in exerting a protective effect against CP and MMC.

摘要

对钝顶螺旋藻进行了测试，以考察其对环磷酰胺（CP）和丝裂霉素C（MMC）诱导的小鼠体内遗传毒性和氧化应激可能具有的保护作用。用钝顶螺旋藻（250、500和1000 mg kg⁻¹，口服，每日一次，共5天）进行预处理，可显著减少染色体损伤和脂质过氧化，同时抗氧化剂和解毒系统也发生相应变化。所有三个测试剂量均能有效发挥对CP和MMC的保护作用。