Ressot C, Collado V, Molat J L, Dallel R
Laboratoire de Physiologie Oro-Faciale, Faculté de Chirurgie Dentaire, 63000 Clermont-Ferrand, France.
J Neurophysiol. 2001 Dec;86(6):3069-72. doi: 10.1152/jn.2001.86.6.3069.
The purpose of this study was to examine the role of glycine in sensory processes in the spinal trigeminal nucleus oralis (Sp5O). We evaluated the effect of intravenous administration of strychnine, a glycine receptor antagonist, on the responses of Sp5O convergent neurons evoked by innocuous peripheral electrical and mechanical stimuli in halothane-anesthetized rats. Strychnine significantly increased the Abeta-fiber-evoked activities of Sp5O neurons to electrical stimulation in a dose-dependent (0.2-0.8 mg/kg) fashion. The response to air-jet stimulation was also significantly enhanced at the highest dose of strychnine. These findings indicate that glycinergic neurons participate in the control of the flow of information conveyed to Sp5O nociceptive neurons by myelinated low-threshold mechanoreceptive afferents. Thus, alteration of trigeminal glycinergic modulation may contribute to the dynamic mechanical allodynia that occurs in trigeminal neuropathies.
本研究的目的是探讨甘氨酸在三叉神经脊束核吻侧亚核（Sp5O）感觉过程中的作用。我们评估了静脉注射士的宁（一种甘氨酸受体拮抗剂）对氟烷麻醉大鼠中无害外周电刺激和机械刺激诱发的Sp5O汇聚神经元反应的影响。士的宁以剂量依赖性（0.2 - 0.8 mg/kg）方式显著增加了Sp5O神经元对电刺激的Aβ纤维诱发活动。在士的宁最高剂量时，对喷气刺激的反应也显著增强。这些发现表明，甘氨酸能神经元参与控制由有髓低阈值机械感受器传入纤维传递至Sp5O伤害性神经元的信息流。因此，三叉神经甘氨酸能调制的改变可能导致三叉神经病变中出现的动态机械性异常性疼痛。
