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致命的阿尼利定-哌替啶联合中毒。气相色谱、薄层色谱和质谱分析研究。

Fatal combined anileridine-pethidine poisoning. A gas chromatography, thin layer chromatography and mass spectrometry investigation.

作者信息

Alha A, Karlsson M, Korte T

出版信息

Z Rechtsmed. 1975;75(4):293-8. doi: 10.1007/BF00201184.

DOI:10.1007/BF00201184
PMID:1173201
Abstract

Anileridine and pethidine were established by gas and thin layer chromatography and mass spectroscopy. In the mass spectrum the main peak of anileridine is found at m/e 246 and that of pethidine at m/e 71. The determination was made by gas chromatography from the blood, urine, liver, muscle and stomach contents.

摘要

通过气相色谱法、薄层色谱法和质谱法鉴定了阿尼利定和哌替啶。在质谱图中,阿尼利定的主峰出现在质荷比为246处,哌替啶的主峰出现在质荷比为71处。通过气相色谱法对血液、尿液、肝脏、肌肉和胃内容物进行了测定。

相似文献

1
Fatal combined anileridine-pethidine poisoning. A gas chromatography, thin layer chromatography and mass spectrometry investigation.致命的阿尼利定-哌替啶联合中毒。气相色谱、薄层色谱和质谱分析研究。
Z Rechtsmed. 1975;75(4):293-8. doi: 10.1007/BF00201184.
2
Comparison of the effect of anileridine and pethidine on the intracholedochal pressure during constant fluid perfusion.持续液体灌注期间阿尼利定与哌替啶对胆总管内压力影响的比较。
Acta Anaesthesiol Scand. 1976;20(2):177-82. doi: 10.1111/j.1399-6576.1976.tb05025.x.
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Radioimmunoassay for anileridine, meperidine and other N-substituted phenylpiperidine carboxylic acid esters.阿尼利定、哌替啶及其他N-取代苯基哌啶羧酸酯的放射免疫分析
Res Commun Chem Pathol Pharmacol. 1975 Oct;12(2):379-87.
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Comparison of haemodynamic effects of pethidine and anileridine in patients with coronary-artery disease.
Acta Anaesthesiol Scand. 1976;20(2):169-76. doi: 10.1111/j.1399-6576.1976.tb05024.x.
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A METHOD FOR THE THIN-LAYER CHROMATOGRAPHY OF ANALGESIC DRUGS AND RELATED COMPOUNDS IN NON-AQUEOUS SYSTEMS.非水体系中镇痛药及相关化合物的薄层色谱分析方法
J Chromatogr. 1965 Mar;17:495-500. doi: 10.1016/s0021-9673(00)99900-x.
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N-dealkylation of anileridine to normeperidine.阿尼利定脱N-烷基生成去甲哌替啶。
J Pharmacol Exp Ther. 1965 Nov;150(2):309-15.
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Comparison of anileridine and pethidine in patients with pain following upper abdominal surgery.
Ann Chir Gynaecol. 1976;65(3):207-15.
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Comparison of haemodynamic effects of pethidine and anileridine in anaesthetised patients.哌替啶与阿尼利定对麻醉患者血流动力学影响的比较。
Acta Anaesthesiol Scand. 1981 Oct;25(5):412-5. doi: 10.1111/j.1399-6576.1981.tb01676.x.
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A case of fatal Lomotil overdosage.一例致命的洛哌丁胺过量服用病例。
Med Sci Law. 1982 Jul;22(3):210-4. doi: 10.1177/002580248202200310.
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Pethidine N-oxide: a metabolite in human urine.哌替啶氮氧化物:人体尿液中的一种代谢物。
J Pharm Pharmacol. 1972 Nov;24(11):915. doi: 10.1111/j.2042-7158.1972.tb08917.x.

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Prevalence of drugs among drivers arrested for drinking and driving in Finland.芬兰因酒驾被捕的司机中药物的流行情况。
Z Rechtsmed. 1977 Apr 18;79(3):225-34. doi: 10.1007/BF00200498.

本文引用的文献

1
Use of acetone in the isolation of organic poisons from biological material.丙酮在从生物材料中分离有机毒物方面的应用。
Ann Med Exp Biol Fenn. 1959;37:149-56.
2
Gas chromatography-mass spectrometry in forensic chemistry for identification of substances isolated from tissue.
Z Rechtsmed. 1971;69(1):52-61. doi: 10.1007/BF02092636.
3
Gas chromatographic determination of drugs in post-mortem blood.气相色谱法测定死后血液中的药物
Ann Med Exp Biol Fenn. 1972;50(4):175-9.
4
The search for a better analgesic.寻找更好的镇痛药。
Science. 1973 Aug 3;181(4098):407-14. doi: 10.1126/science.181.4098.407.