Alha A R, Karlsson M, Linnoila M, Lukkari I
Z Rechtsmed. 1977 Apr 18;79(3):225-34. doi: 10.1007/BF00200498.
A combined thin layer and gas chromatography system was developed for qualitative and quantitative analysis of drugs in biological samples after extraction with heptane-isoamyl alcohol. Both acidic and basic extraction procedures were used. Special methods were used for the extraction and detection of salicylates, isoniazid, and morphine. Particular attention was given to the detection of psychostimulants; though these drugs have seldom been found in drinking drivers in Finland they are commonly found in Sweden. Two percent of all suspected drinking drivers were also suspected of concommitant drug use, which led to primary sampling of urine. Of 100 such drivers, 24 had blood alcohol levels (BALs) which were negative and 18 of that 24 had drugs in their sample. Seventy-six of the 100 had positive BALs and 25 of the 76 had drugs in their samples. Of the randomly chosen 100 suspected drinking drivers, 5 had drugs in their samples, and 4 of these 5 had positive BALs. The benzodiazeomes were the most commonly detected drugs. No stimulants were found in our subjects.
开发了一种薄层色谱和气相色谱联用系统，用于对生物样品中的药物进行定性和定量分析，生物样品先用庚烷 - 异戊醇萃取。酸性和碱性萃取程序均被采用。采用特殊方法萃取和检测水杨酸盐、异烟肼和吗啡。特别关注了精神兴奋剂的检测；尽管在芬兰酒后驾车者中很少发现这些药物，但在瑞典却很常见。所有疑似酒后驾车者中有2%也被怀疑同时使用药物，这导致对尿液进行初次采样。在100名此类驾车者中，24人的血液酒精含量（BALs）呈阴性，这24人中的18人样本中含有药物。100人中的76人BALs呈阳性，这76人中的25人样本中含有药物。在随机选取的100名疑似酒后驾车者中，5人样本中含有药物，这5人中的4人BALs呈阳性。苯二氮卓类药物是最常检测到的药物。在我们的研究对象中未发现兴奋剂。
