Takeda Y, Satoh M, Nakamura S, Yamamoto H
Department of Oral Pathology, School of Dentistry, Iwate Medical University, Morioka, Japan.
J Oral Sci. 2001 Sep;43(3):165-9. doi: 10.2334/josnusd.43.165.
Papillary squamous cell carcinoma (PSCC) is a poorly described variant of squamous cell carcinoma, and may be confused with verrucous carcinoma of the head and neck. To add to existing knowledge of this rare tumor, we describe two cases of PSCC arising in the oral mucosa. The lesions were composed of exophytic proliferation of atypical to overtly malignant cells similar to those of conventional squamous cell carcinoma, and invasion into the superficial region of the underlying fibrous tissue was seen in the form of islands and cords of malignant cells. Immunohistochemical assessment of cellular proliferative activity showed a significantly high mean percentage of Ki-67 expression in comparison with verrucous carcinoma, but there was no significant difference of Ki-67 expression among PSCC, conventional squamous cell carcinoma and microinvasive squamous cell carcinoma. These results suggest that the biological behavior of PSCC is analogous to that of SCC.
乳头状鳞状细胞癌（PSCC）是一种描述较少的鳞状细胞癌变体，可能会与头颈部疣状癌混淆。为了增加对这种罕见肿瘤的现有认识，我们描述了两例发生于口腔黏膜的PSCC病例。病变由非典型至明显恶性细胞的外生性增殖组成，类似于传统鳞状细胞癌，并且可见恶性细胞以岛状和条索状形式侵入下方纤维组织的浅表区域。细胞增殖活性的免疫组织化学评估显示，与疣状癌相比，Ki-67表达的平均百分比显著较高，但在PSCC、传统鳞状细胞癌和微侵袭性鳞状细胞癌之间，Ki-67表达没有显著差异。这些结果表明，PSCC的生物学行为与鳞状细胞癌类似。
