Breccia M, Girmenia C, Mecarocci S, Cartoni C, Carmosino I, Tafuri A, Alimena G
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy.
Ann Hematol. 2001 Oct;80(10):614-6. doi: 10.1007/s002770100337.
Acute colonic pseudo-obstruction, the so-called Ogilvie's syndrome, is a rare and life-threatening digestive complication usually observed in critically ill patients. It is characterized by signs of large-bowel obstruction, without a mechanical cause, and has been reported in various settings, including acute leukemias as a complication of neutropenic enterocolitis after intensive chemotherapy. We describe the case of a young woman who, during the neutropenic phase following autologous bone marrow transplantation for relapsed acute myeloid leukemia, developed neutropenic enterocolitis complicated by an acute pseudo-obstruction of descendent colon and sigma. This process was associated with sepsis and resolved with conservative therapy of the underlying condition, using granulocyte colony-stimulating factor and intravenous neostigmine. We discuss the management of this rare syndrome.
急性结肠假性梗阻，即所谓的奥吉尔维综合征，是一种罕见且危及生命的消化系统并发症，通常在危重症患者中出现。其特征为大肠梗阻的体征，但无机械性病因，已在多种情况下被报道，包括急性白血病，作为强化化疗后中性粒细胞减少性小肠结肠炎的并发症。我们描述了一名年轻女性的病例，她在因复发性急性髓系白血病进行自体骨髓移植后的中性粒细胞减少期，发生了中性粒细胞减少性小肠结肠炎，并伴有降结肠和乙状结肠急性假性梗阻。该过程与脓毒症相关，通过使用粒细胞集落刺激因子和静脉注射新斯的明对基础疾病进行保守治疗后得以缓解。我们讨论了这种罕见综合征的治疗方法。
