Kim H J, Na H S, Back S K, Hong S K
Neuroscience Research Institute and Department of Physiology, Korea University College of Medicine, 126-1, Anam-dong 5 ga, Sungbuk-gu, Seoul, 136-705, Korea.
Neuroreport. 2001 Nov 16;12(16):3529-32. doi: 10.1097/00001756-200111160-00031.
We examined whether the extent of sympathetic sprouting in the dorsal root ganglion was a function of the number of injured nerve fibers. We compared two groups of rats. One group was subjected to unilateral superior and inferior caudal trunk transections at the level between the S1 and S2 spinal nerves (S-I group) and the other group was subjected to unilateral superior caudal trunk transection at the same level (S group). Immunohistochemical staining with tyrosine hydroxylase (TH) antibody of the S1 DRG revealed that the degree of TH-immunoreactive fibers was more extensive in the S-I group than in the S group. However, there was no difference in the severity of neuropathic pain behaviors between the two groups. These results suggest that the extent of sympathetic sprouting in the DRG following peripheral nerve injury is proportionally related to the amount of injured nerve fibers, but not related to the degree of neuropathic pain behaviors.
我们研究了背根神经节中交感神经芽生的程度是否是受损神经纤维数量的函数。我们比较了两组大鼠。一组在S1和S2脊神经之间的水平进行单侧上、下尾干横断（S-I组），另一组在同一水平进行单侧上尾干横断（S组）。用酪氨酸羟化酶（TH）抗体对S1背根神经节进行免疫组织化学染色显示，S-I组中TH免疫反应性纤维的程度比S组更广泛。然而，两组之间神经病理性疼痛行为的严重程度没有差异。这些结果表明，周围神经损伤后背根神经节中交感神经芽生的程度与受损神经纤维的数量成比例相关，但与神经病理性疼痛行为的程度无关。
