Kim H J, Na H S, Sung B, Hong S K
Neuroscience Research Institute and Department of Physiology, Korea University College of Medicine, Seoul, South Korea.
Neurosci Lett. 1998 Mar 27;245(1):21-4. doi: 10.1016/s0304-3940(98)00167-0.
Incomplete peripheral nerve injury often leads to neuropathic pains, some of which are relieved by sympathectomy, and results in sympathetic postganglionic nerve fiber sprouting in the dorsal root ganglion (DRG). This study was performed to see whether the sprouting in the DRG plays a key role in the sympathetic dependence of neuropathic pain. To this aim, we compared two groups of rats, both of which were subjected to unilateral transection of the inferior and superior caudal trunks at the levels between the S1 and S2, S2 and S3, and S3 and S4 spinal nerves, with respect to sympathetic fiber sprouting; one group showed neuropathic pain behaviours (i.e. mechanical and cold allodynia signs) which were very sensitive to phentolamine, alpha adrenergic blocker, and the other group exhibited no sensitivity. Immuno-histochemical staining with tyrosine hydroxylase antibody of the S1-S3 DRGs was not correlated with the sensitivity to phentolamine. These results suggest that the degree of sympathetic dependence of neuropathic pain is not a function of the extent of the sympathetic postganglionic nerve fiber sprouting in the DRG.
不完全性周围神经损伤常导致神经性疼痛，其中一些疼痛可通过交感神经切除术缓解，并导致背根神经节（DRG）中交感神经节后神经纤维发芽。本研究旨在观察DRG中的发芽是否在神经性疼痛的交感神经依赖性中起关键作用。为此，我们比较了两组大鼠，两组均在S1和S2、S2和S3以及S3和S4脊神经之间的水平进行单侧尾下干和尾上干横断，以观察交感神经纤维发芽情况；一组表现出对酚妥拉明（一种α肾上腺素能阻滞剂）非常敏感的神经性疼痛行为（即机械性和冷觉异常性疼痛体征），而另一组则无敏感性。用酪氨酸羟化酶抗体对S1 - S3 DRG进行免疫组织化学染色与对酚妥拉明的敏感性无关。这些结果表明，神经性疼痛的交感神经依赖程度不是DRG中交感神经节后神经纤维发芽程度的函数。
