Bartek J, Falck J, Lukas J
Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK-2100 Copenhagen Ø, Denmark.
Nat Rev Mol Cell Biol. 2001 Dec;2(12):877-86. doi: 10.1038/35103059.
Checkpoint kinase 2 (Chk2) is emerging as a key mediator of diverse cellular responses to genotoxic stress, guarding the integrity of the genome throughout eukaryotic evolution. Recent studies show the fundamental role of Chk2 in the network of genome-surveillance pathways that coordinate cell-cycle progression with DNA repair and cell survival or death. Defects in Chk2 contribute to the development of both hereditary and sporadic human cancers, and earmark this kinase as a candidate tumour suppressor and an attractive target for drug discovery.
检验点激酶2（Chk2）正逐渐成为细胞对基因毒性应激多种反应的关键调节因子，在整个真核生物进化过程中维护基因组的完整性。最近的研究表明，Chk2在基因组监测途径网络中发挥着重要作用，该网络可协调细胞周期进程与DNA修复以及细胞存活或死亡。Chk2的缺陷会导致遗传性和散发性人类癌症的发生，这使该激酶成为候选肿瘤抑制因子以及药物研发的一个有吸引力的靶点。
