Tsvetkov Lyuben
Department of Pathology, School of Medicine, Yale University, New Haven, Connecticut 06510, USA.
IUBMB Life. 2004 Aug;56(8):449-56. doi: 10.1080/15216540400010826.
The cell cycle controls processes of DNA replication and segregation of replicated DNA into two daughter cells. These processes are coordinated by multiple signaling pathways, which employ many protein kinases. The members of the family of Polo-like protein kinases are among these key cell cycle regulators. In response to DNA damage and inhibited DNA replication, DNA structure checkpoints delay cell cycle progression to provide cells with time for repair of damaged DNA and protect it from more severe damage. These effects are achieved by affecting key players of the basic cell cycle regulation of the cells with damaged DNA. This review is focused on the interplay between Chk2, a bona fide checkpoint protein kinase, and Polo-like kinases.
细胞周期控制着DNA复制过程以及将复制后的DNA分离到两个子细胞中的过程。这些过程由多种信号通路协调，这些信号通路使用了许多蛋白激酶。Polo样蛋白激酶家族的成员是这些关键的细胞周期调节因子之一。响应DNA损伤和DNA复制受抑制，DNA结构检查点会延迟细胞周期进程，以便为细胞提供时间来修复受损的DNA并保护其免受更严重的损伤。这些作用是通过影响受损DNA细胞基本细胞周期调控的关键参与者来实现的。本综述聚焦于真正的检查点蛋白激酶Chk2与Polo样激酶之间的相互作用。
