Baughman R P, Teirstein A S, Judson M A, Rossman M D, Yeager H, Bresnitz E A, DePalo L, Hunninghake G, Iannuzzi M C, Johns C J, McLennan G, Moller D R, Newman L S, Rabin D L, Rose C, Rybicki B, Weinberger S E, Terrin M L, Knatterud G L, Cherniak R
University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0565, USA.
Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1885-9. doi: 10.1164/ajrccm.164.10.2104046.
Sarcoidosis may be affected by sex, race, and age. A Case Control Etiologic Study of Sarcoidosis (ACCESS) enrolled 736 patients with sarcoidosis within 6 mo of diagnosis from 10 clinical centers in the United States. Using the ACCESS sarcoidosis assessment system, we determined organ involvement for the whole group and for subgroups differentiated by sex, race, and age (less than 40 yr or 40 yr and older). The study population was heterogeneous in terms of race (53% white, 44% black), sex (64% female, 36% male), and age (46% < 40 yr old, 54% > or = 40 yr old). Women were more likely to have eye and neurologic involvement (chi(2) = 4.74, p < 0.05 and chi(2) = 4.60, p < 0.05 respectively), have erythema nodosum (chi(2) = 7.28, p < 0.01), and to be age 40 yr or over (chi(2) = 6.07, p < 0.02) whereas men were more likely to be hypercalcemic (chi(2) = 7.38, p < 0.01). Black subjects were more likely to have skin involvement other than erythema nodosum (chi(2) = 5.47, p < 0.05), and eye (chi(2) = 13.8, p < 0.0001), liver (chi(2) = 23.3, p < 0.0001), bone marrow (chi(2) = 18.8, p < 0.001), and extrathoracic lymph node involvement (chi(2) = 7.21, p < 0.01). We conclude that the initial presentation of sarcoidosis is related to sex, race, and age.
结节病可能受性别、种族和年龄的影响。结节病病例对照病因学研究（ACCESS）纳入了来自美国10个临床中心、诊断后6个月内的736例结节病患者。使用ACCESS结节病评估系统，我们确定了整个研究组以及按性别、种族和年龄（小于40岁或40岁及以上）区分的亚组的器官受累情况。研究人群在种族（53%为白人，44%为黑人）、性别（64%为女性，36%为男性）和年龄（46%小于40岁，54%大于或等于40岁）方面具有异质性。女性更易出现眼部和神经系统受累（分别为χ² = 4.74，p < 0.05和χ² = 4.60，p < 0.05）、结节性红斑（χ² = 7.28，p < 0.01），且年龄在40岁及以上（χ² = 6.07，p < 0.02），而男性更易出现高钙血症（χ² = 7.38，p < 0.01）。黑人受试者更易出现除结节性红斑之外的皮肤受累（χ² = 5.47，p < 0.05）、眼部受累（χ² = 13.8，p < 0.0001）、肝脏受累（χ² = 23.3，p < 0.0001）、骨髓受累（χ² = 18.8，p < 0.001）以及胸外淋巴结受累（χ² = 7.21，p < 0.01）。我们得出结论，结节病的初始表现与性别、种族和年龄有关。
