Ahsan Erna, Singh Shalini, Kumar Gautam Saurabh, Chandra Harish, Balasubramanian Priyavadhana, Kumar Gupta Arvind, Singh Neha
All India Institute of Medical Sciences Rishikesh, Rishikesh, India.
J Hematop. 2025 Jul 11;18(1):32. doi: 10.1007/s12308-025-00647-5.
Granulomas in a bone marrow biopsy are like gold dust. Numerous studies have reported that the incidence of granulomas in bone marrow biopsies ranges from 0.3 to 2.2%. In developing countries such as India, tuberculosis is the most common cause of bone marrow granulomas; nonetheless, the etiologic spectrum includes a broad range of disorders. To better understand granulomatous inflammation in the bone marrow and prevent its misinterpretation, this study aims to highlight the variety of disorders, including infectious and non-infectious causes, that are linked to this finding. This is a retrospective study which was conducted in the Department of Pathology and Laboratory Medicine at All India Institute of Medical Sciences, Rishikesh. Bone marrow biopsies with granulomatous inflammation reported over a period of 3 years, from 2022 to 2024, were reviewed for their clinical and laboratory features and included in this study. We identified 22 cases among 3485 bone marrow biopsies, representing an incidence of 0.63% in the series. Among the 22 patients, the most common etiology was infectious (59.1%), followed by malignancy (36.34%), and sarcoidosis (4.5%). Marrow granulomas should prompt a thorough investigation into the underlying cause. It is hoped that this article would help in guiding the investigation for potential causes.
骨髓活检中的肉芽肿犹如凤毛麟角。众多研究报告称，骨髓活检中肉芽肿的发生率在0.3%至2.2%之间。在印度等发展中国家，结核病是骨髓肉芽肿最常见的病因；尽管如此，病因范围涵盖了广泛的疾病。为了更好地理解骨髓中的肉芽肿性炎症并防止其被误诊，本研究旨在突出与这一发现相关的各种疾病，包括感染性和非感染性病因。这是一项回顾性研究，在瑞诗凯诗全印度医学科学研究所病理与检验医学系开展。对2022年至2024年期间报告有肉芽肿性炎症的骨髓活检的临床和实验室特征进行了回顾，并纳入本研究。我们在3485例骨髓活检中识别出22例，该系列中的发生率为0.63%。在这22例患者中，最常见的病因是感染性（59.1%），其次是恶性肿瘤（36.34%）和结节病（4.5%）。骨髓肉芽肿应促使对潜在病因进行全面调查。希望本文有助于指导对潜在病因的调查。
