Pascot A, Lemieux I, Prud'homme D, Tremblay A, Nadeau A, Couillard C, Bergeron J, Lamarche B, Després J P
Lipid Research Center, CHUL Research Center, Ste-Foy, Québec, Canada.
J Lipid Res. 2001 Dec;42(12):2007-14.
Reduced plasma HDL cholesterol concentration has been associated with an increased risk of coronary heart disease. However, a low HDL cholesterol concentration is usually not observed as an isolated disorder because this condition is often accompanied by additional metabolic alterations. The objective of this study was to document the relevance of assessing HDL particle size as another feature of the atherogenic dyslipidemia found among subjects with visceral obesity and insulin resistance. For that purpose, an average HDL particle size was computed by calculating an integrated HDL particle size using nondenaturing 4-30% gradient gel electrophoresis. Potential associations between this average HDL particle size versus morphometric and metabolic features of visceral obesity were examined in a sample of 238 men. Results of this study indicated that HDL particle size was a significant correlate of several features of an atherogenic dyslipidemic profile such as increased plasma TG, decreased HDL cholesterol, high apolipoprotein B, elevated cholesterol/HDL cholesterol ratio, and small LDL particles as well as increased levels of visceral adipose tissue (AT) (0.33 < or = absolute value of r < or = 0.61, P < 0.0001). Thus, men with large HDL particles had a more favorable plasma lipoprotein-lipid profile compared with those with smaller HDL particles. Furthermore, men with large HDL particles were also characterized by reduced overall adiposity and lower levels of visceral AT as well as reduced insulinemic-glycemic responses to an oral glucose load. In conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia.
血浆高密度脂蛋白（HDL）胆固醇浓度降低与冠心病风险增加相关。然而，低HDL胆固醇浓度通常不会作为一种孤立的病症被观察到，因为这种情况常伴有其他代谢改变。本研究的目的是证明评估HDL颗粒大小作为内脏肥胖和胰岛素抵抗受试者中发现的致动脉粥样硬化血脂异常的另一个特征的相关性。为此，通过使用非变性4 - 30%梯度凝胶电泳计算综合HDL颗粒大小来计算平均HDL颗粒大小。在238名男性样本中检查了这种平均HDL颗粒大小与内脏肥胖的形态学和代谢特征之间的潜在关联。本研究结果表明，HDL颗粒大小与致动脉粥样硬化血脂异常的几个特征显著相关，如血浆甘油三酯（TG）升高、HDL胆固醇降低、载脂蛋白B升高、胆固醇/HDL胆固醇比值升高、小低密度脂蛋白（LDL）颗粒以及内脏脂肪组织（AT）水平升高（0.33≤r的绝对值≤0.61，P<0.0001）。因此，与HDL颗粒较小的男性相比，HDL颗粒较大的男性具有更有利的血浆脂蛋白 - 脂质谱。此外，HDL颗粒较大的男性还具有总体肥胖程度降低、内脏AT水平较低以及口服葡萄糖负荷后胰岛素 - 血糖反应降低的特征。总之，小HDL颗粒大小似乎代表了在内脏肥胖受试者中发现的高TG - 低HDL胆固醇血脂异常的另一个特征，这些受试者以高胰岛素血症为特征。
