Dissecting the transcriptional network of pancreatic islets during development and differentiation.
作者信息
Shih D Q, Stoffel M
机构信息
Laboratory of Metabolic Diseases, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
出版信息
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14189-91. doi: 10.1073/pnas.251558998.
Abstract
摘要
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本文引用的文献
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A transcription factor regulatory circuit in differentiated pancreatic cells.分化胰腺细胞中的转录因子调控回路。
Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14481-6. doi: 10.1073/pnas.241349398. Epub 2001 Nov 20.
2
Loss of HNF-1alpha function in mice leads to abnormal expression of genes involved in pancreatic islet development and metabolism.小鼠中肝细胞核因子-1α（HNF-1α）功能丧失会导致参与胰岛发育和代谢的基因表达异常。
Diabetes. 2001 Nov;50(11):2472-80. doi: 10.2337/diabetes.50.11.2472.
3
A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young.肝细胞核因子4α基因的一个远距离上游启动子将参与青年发病型糖尿病的转录因子联系起来。
Hum Mol Genet. 2001 Sep 15;10(19):2089-97. doi: 10.1093/hmg/10.19.2089.
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Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young.青年发病型成年糖尿病的分子机制与临床病理生理学
N Engl J Med. 2001 Sep 27;345(13):971-80. doi: 10.1056/NEJMra002168.
5
Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets.胚胎干细胞分化为类似于胰岛的胰岛素分泌结构。
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