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就与治疗相关的勃起功能障碍问题为前列腺癌患者提供咨询。

Counselling the patient with prostate cancer about treatment-related erectile dysfunction.

作者信息

Montorsi F, Salonia A, Zanoni M, Colombo R, Pompa P, Rigatti P

机构信息

Department of Urology, 'Vita e Salute' University--San Raffaele, Milan, Italy.

出版信息

Curr Opin Urol. 2001 Nov;11(6):611-7. doi: 10.1097/00042307-200111000-00009.

Abstract

At present, a significant proportion of patients with prostate cancer are diagnosed at an early stage and may receive treatments able to bring about the long-term control of the disease. Thus, the impact of available treatments on the patient's quality of life has been gaining increasing importance; for patients with prostate cancer, counselling on the treatment-related effects on sexual function has become mandatory. Radical prostatectomy is very frequently performed in patients with clinically localized prostate cancer. Postoperative erectile function has been reported as being satisfactory in the majority of the patients operated on in centers of excellence for this procedure. However, overall, the results for postoperative potency are disappointing in view of the large amounts of data available from community practices. Attempts to improve postoperative potency include the intraoperative use of cavernous nerve stimulation and grafting of peripheral nerves to restore the innervation of the corpora cavernosa. Erectile dysfunction has also been associated with prostate radiotherapy. It has been shown that both ultrasound-guided brachytherapy and three-dimensional conformal radiation therapy cause an impairment of erectile function that is usually seen some time after the completion of therapy. Treatment with sildenafil citrate remains a viable option both for patients treated with radical prostatectomy (in whom the cavernous nerve function is at least partially present) and in patients treated with radiotherapy.

摘要

目前,相当一部分前列腺癌患者在早期被诊断出来,可能会接受能够实现疾病长期控制的治疗。因此,现有治疗方法对患者生活质量的影响变得越来越重要;对于前列腺癌患者,关于治疗对性功能影响的咨询已成为必需。根治性前列腺切除术在临床局限性前列腺癌患者中非常常见。据报道,在进行该手术的卓越中心,大多数接受手术的患者术后勃起功能令人满意。然而,总体而言,从社区实践获得的大量数据显示,术后性功能恢复的结果令人失望。改善术后性功能的尝试包括术中使用海绵体神经刺激以及移植周围神经以恢复海绵体的神经支配。勃起功能障碍也与前列腺放疗有关。研究表明,超声引导下近距离放疗和三维适形放疗都会导致勃起功能受损,这种情况通常在治疗结束后的一段时间内出现。枸橼酸西地那非治疗对于接受根治性前列腺切除术的患者(其海绵体神经功能至少部分存在)以及接受放疗的患者仍然是一种可行的选择。

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