Aydogdu I, Sari R, Ulu R, Sevinc A
Department of Hematology, Inonu University, School of Medicine, Turgut Ozal Medical Center, TR-44069, Malatya, Turkey.
J Surg Res. 2001 Dec;101(2):120-3. doi: 10.1006/jsre.2001.6269.
Ineffective erythropoiesis and intramedullary hemolysis are the two important results of pernicious anemia. Hemolysis is one of the risk factors in the formation of gallbladder stones.
The frequency of gallstones was searched in 59 patients with pernicious anemia and in 54 healthy subjects.
Nineteen (32.2%) patients in the pernicious anemia group and three (5.5%) patients in the control group were detected to have gallstones. Pernicious anemia patients with and without gallbladder stones were also compared for mean corpuscular volume, hemoglobin, unconjugated bilirubin, lactic dehydrogenase, and vitamin B12 levels but no statistically significant difference was encountered.
Apart from other risk factors, pernicious anemia itself increases the frequency of gallbladder stones. Should patients with pernicious anemia develop upper-abdominal pain or other symptoms referable to biliary tract disease, a high index of suspicion for gallstone-related disease should be maintained.
无效红细胞生成和骨髓内溶血是恶性贫血的两个重要后果。溶血是胆囊结石形成的危险因素之一。
对59例恶性贫血患者和54例健康受试者进行胆囊结石发生率调查。
恶性贫血组有19例（32.2%）患者被检测出有胆囊结石，对照组有3例（5.5%）患者被检测出有胆囊结石。还比较了有和没有胆囊结石的恶性贫血患者的平均红细胞体积、血红蛋白、非结合胆红素、乳酸脱氢酶和维生素B12水平，但未发现有统计学意义的差异。
除其他危险因素外，恶性贫血本身会增加胆囊结石的发生率。如果恶性贫血患者出现上腹部疼痛或其他与胆道疾病相关的症状，应高度怀疑与胆囊结石相关的疾病。
