Li Q Z, Lu Z Q
Laboratory of Theoretical Biophysics, Inner Mongolia University, Hohhot, 010021, China.
J Theor Biol. 2001 Dec 7;213(3):493-502. doi: 10.1006/jtbi.2001.2441.
Based on the concept that the structural class of a protein is mainly determined by its secondary structure sequence, a new algorithm for prediction of the structural class of a protein is proposed. By use of the number of alpha -helices, beta -strands, and betaalphabeta fragments, the structural class of a protein can be predicted by an algorithm based on the increment of diversity (ID), in which the sole prediction parameter-the increment of diversity is used as the index of prediction of structural class of a protein. The results indicate that the high rates of correct prediction are obtained for complete set (standard set) from Brookhaven Protein Data Bank-CD ROM (PDB) published in October 1995 and the test set newly released from Brookhaven Protein Data Bank-CD ROM (PDB) before July 1998, respectively.
基于蛋白质的结构类别主要由其次级结构序列决定这一概念，提出了一种预测蛋白质结构类别的新算法。通过使用α螺旋、β链和βαβ片段的数量，可以通过基于多样性增量（ID）的算法预测蛋白质的结构类别，其中唯一的预测参数——多样性增量被用作蛋白质结构类别预测的指标。结果表明，分别对1995年10月出版的布鲁克海文蛋白质数据库光盘（PDB）中的完整数据集（标准集）和1998年7月之前从布鲁克海文蛋白质数据库光盘（PDB）新发布的测试集获得了较高的正确预测率。
