Neumann C J
Developmental Biology Programme, EMBL, Meyerhofstrasse 1, Postfach 10.2209, D-69012 Heidelberg, Germany.
Semin Cell Dev Biol. 2001 Dec;12(6):485-90. doi: 10.1006/scdb.2001.0272.
During the past 15 years, the zebrafish has become established as a genetic model organism to study vertebrate development. It is particularly well suited for the analysis of the retina, and several genetic screens have yielded a large number of mutants affecting retinal development. Most of these mutants still await thorough analysis and molecular characterization, but work on a handful of genes has already generated interesting results that shed some light on patterning mechanisms employed in the vertebrate retina.
在过去的15年里,斑马鱼已成为一种用于研究脊椎动物发育的遗传模式生物。它特别适合用于视网膜分析,多项遗传筛选已产生大量影响视网膜发育的突变体。这些突变体中的大多数仍有待深入分析和分子表征,但对少数基因的研究已经产生了有趣的结果,这些结果为脊椎动物视网膜中所采用的模式形成机制提供了一些线索。