Eremia S, Li C Y, Umar S H, Newman N
Division of Dermatology, UCLA, Los Angeles, California, USA.
Dermatol Surg. 2001 Nov;27(11):920-4. doi: 10.1046/j.1524-4725.2001.01074.x.
Hypertrichosis is a common problem for which laser hair removal is becoming the treatment of choice. Optimal wavelength, pulse duration, spot size, fluence, and skin cooling parameters for various skin types have not yet been firmly established.
To evaluate the long-term efficacy and safety of a 3-msec 755 nm alexandrite laser equipped with a cryogen cooling device for patients with Fitzpatrick skin types I-V.
Eighty-nine untanned patients with skin types I-V underwent a total of 492 treatments of laser hair removal over a 15-month period. Each patient in the study underwent a minimum of three treatment sessions spaced 4-6 weeks apart (mean treatments 5.6). Retrospective chart review and patient interviews were used to establish hair reduction results. Treatment sites included the axillae, bikini, extremities, face, and trunk. A 3-msec pulse width, 755 nm alexandrite laser equipped with a cryogen spray cooling device was used in this study. Spot sizes of 10-15 mm were used. A spot size of 10 mm was used for fluences greater than 40 J/cm(2), a spot size of 12 mm was used for fluences of 35-40 J/cm(2), and spot sizes of 12 and 15 mm were used for fluences less than 30 J/cm(2). Fluences ranging from 20 to 50 J/cm(2) (mean fluence 36 J/cm(2)) were used.
The patients had a mean 74% hair reduction. Skin type I patients had an average of 78.5% hair reduction using a mean fluence of 40 J/cm(2) (35-50 J/cm(2)) and a 10-12 mm spot size (12 mm in more than 95% of treatments). Skin type II patients had a mean 74.3% hair reduction using a mean fluence of 38 J/cm(2) (30-40 J/cm2) and a 12-15 mm spot size. Skin type III patients had a mean 73.4% hair reduction using a mean fluence of 37 J/cm(2) (25-40 J/cm(2)) and a 12-15 mm spot size. Skin type IV patients had a mean 71.0% hair reduction using a mean fluence of 31 J/cm2 (25-35 J/cm(2)) and a 12-15 mm spot size. A patient with skin type V had a 60% hair reduction using a mean fluence of 23 J/cm(2) (20-25 J/cm(2)) and a 12-15 mm spot size. The efficiency of hair removal directly correlates significantly with the fluence used. Rare side effects included transient postinflammatory hyperpigmentation (n = 9; 10%), burn with blisters (n = 1; 1%), and postinflammatory hypopigmentation (n = 2; 2%). All complications resolved without permanent scarring.
The 3-msec cryogen cooling-equipped alexandrite laser can safely and effectively achieve long-term hair removal in patients with skin types I-V. The best results are achieved in untanned patients with skin types I-IV.
多毛症是一个常见问题,激光脱毛正成为首选治疗方法。针对不同皮肤类型的最佳波长、脉冲持续时间、光斑大小、能量密度和皮肤冷却参数尚未完全确定。
评估配备冷冻剂冷却装置的3毫秒755纳米翠绿宝石激光对Fitzpatrick皮肤分型为I - V型患者的长期疗效和安全性。
89例未晒黑的I - V型皮肤患者在15个月内共接受了492次激光脱毛治疗。研究中的每位患者至少接受三次治疗,每次间隔4 - 6周(平均治疗5.6次)。通过回顾病历和患者访谈来确定毛发减少情况。治疗部位包括腋窝、比基尼线、四肢、面部和躯干。本研究使用配备冷冻剂喷雾冷却装置的3毫秒脉宽、755纳米翠绿宝石激光。光斑大小为10 - 15毫米。能量密度大于40 J/cm²时使用10毫米光斑,能量密度为35 - 40 J/cm²时使用12毫米光斑,能量密度小于30 J/cm²时使用12毫米和15毫米光斑。能量密度范围为20 - 50 J/cm²(平均能量密度36 J/cm²)。
患者毛发平均减少74%。I型皮肤患者使用平均能量密度40 J/cm²(35 - 50 J/cm²)和10 - 12毫米光斑大小(超过95%的治疗使用12毫米光斑),毛发平均减少78.5%。II型皮肤患者使用平均能量密度38 J/cm²(30 - 40 J/cm²)和12 - 15毫米光斑大小,毛发平均减少74.3%。III型皮肤患者使用平均能量密度37 J/cm²(25 - 40 J/cm²)和12 - 15毫米光斑大小,毛发平均减少73.4%。IV型皮肤患者使用平均能量密度31 J/cm²(25 - 35 J/cm²)和12 - 15毫米光斑大小,毛发平均减少71.0%。一名V型皮肤患者使用平均能量密度23 J/cm²(20 - 25 J/cm²)和12 - 15毫米光斑大小,毛发减少60%。脱毛效率与所使用的能量密度直接显著相关。罕见的副作用包括短暂的炎症后色素沉着(n = 9;10%)、水疱性烧伤(n = 1;1%)和炎症后色素减退(n = 2;2%)。所有并发症均已解决,未留下永久性疤痕。
配备3毫秒冷冻剂冷却的翠绿宝石激光能够安全有效地对I - V型皮肤患者实现长期脱毛。I - IV型未晒黑的患者效果最佳。