McDaniel D H, Lord J, Ash K, Newman J, Zukowski M
Laser Center of Virginia, Virginia Beach 23454-3101, USA.
Dermatol Surg. 1999 Jun;25(6):425-30. doi: 10.1046/j.1524-4725.1999.08118.x.
The mechanism and permanence of laser-assisted hair removal remains a formidable task in the medical community.
The purpose of this study was to determine the safety and long-term efficacy of the long-pulsed or normal mode alexandrite infrared laser for hair depilation.
Beginning in October 1996, a total of 31 anatomic sites on 22 patients ranging in age from 25 to 59 years (mean 42 years) were evaluated to assess hair removal. Treatment sites included 17 upper lips, 9 legs, 2 backs, and 3 bikini regions. Eligible patients were of Fitzpatrick skin types I-III. Patients were treated using the long-pulsed alexandrite infrared laser at 755 nm, single-pulse technique, 10 mm spot size, 10% overlap, pulse durations of 5, 10, and 20 msec, and a fluence of 20 J/cm2. Subjective patient improvement and objective, blinded graded improvement was assessed at 1, 2, 3, and 6 months.
Objective blinded grading at 6 months revealed that hair reduction varied both with the pulse duration and anatomic location. Maximum reductions observed were 40%, 56%, 50%, and 15% for the lip, leg, back, and bikini areas, respectively. Upper lip hair reduction increased from 40% to 54% at 6 months when a second treatment was performed 8 weeks after the initial treatment.
The long-pulsed alexandrite laser is safe and effective in reducing hair growth. Treatment efficacy varies with the anatomic location, pulse duration, and number of treatments. A single-pulse technique utilizing a 10 msec pulse duration at 20 J/cm2 produced the greatest hair reduction. No permanent adverse effects occurred on skin types I-III at the parameters tested.
激光辅助脱毛的机制和持久性在医学界仍是一项艰巨的任务。
本研究的目的是确定长脉冲或常规模式翠绿宝石红外激光用于脱毛的安全性和长期疗效。
从1996年10月开始,对22例年龄在25至59岁(平均42岁)的患者的31个解剖部位进行了评估以评估脱毛情况。治疗部位包括17个上唇、9条腿部、2个背部和3个比基尼区域。符合条件的患者为菲茨帕特里克皮肤分型I - III型。患者使用755nm的长脉冲翠绿宝石红外激光进行治疗,采用单脉冲技术,光斑大小为10mm,重叠率为10%,脉冲持续时间为5、10和20毫秒,能量密度为20J/cm²。在1、2、3和6个月时评估患者主观改善情况以及客观、盲法分级改善情况。
6个月时的客观盲法分级显示,毛发减少情况随脉冲持续时间和解剖部位而有所不同。上唇、腿部、背部和比基尼区域观察到的最大毛发减少率分别为40%、56%、50%和15%。初次治疗8周后进行第二次治疗时,6个月时上唇毛发减少率从40%增加到了54%。
长脉冲翠绿宝石激光在减少毛发生长方面是安全有效的。治疗效果随解剖部位、脉冲持续时间和治疗次数而变化。在20J/cm²能量密度下采用10毫秒脉冲持续时间的单脉冲技术产生的毛发减少效果最佳。在所测试的参数下,I - III型皮肤未出现永久性不良反应。