Burger A
Arzneimittelforschung. 1975 Jan;25(1):24-27.
The solubility and dissolution rate of five different solid forms of 7-chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-o-tolyl-6-quinazoline-sulfonamide (metolazone) in n-butanol, water and 0.01 n HCl are investigated and thermodynamic values have been computed. The amorphous metolazone dissolves about 8 times faster than the stable modification I (mp. 267-270 degrees C) in 0.01 n HCl at 37 degrees C.
研究了7-氯-1,2,3,4-四氢-2-甲基-4-氧代-邻甲苯基-6-喹唑啉磺酰胺（美托拉宗）五种不同固体形式在正丁醇、水和0.01N盐酸中的溶解度和溶解速率，并计算了热力学值。在37℃的0.01N盐酸中，无定形美托拉宗的溶解速度比稳定变体I（熔点267 - 270℃）快约8倍。
