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一名特发性肺含铁血黄素沉着症患儿的羟氯喹耳毒性

Hydroxychloroquine ototoxicity in a child with idiopathic pulmonary haemosiderosis.

作者信息

Coutinho Miguel B, Duarte Idalinda

机构信息

Department of Otolaryngology, Hospital de Crianças Maria Pia, Rua da Boavista 827, 4050-111, Porto, Portugal.

出版信息

Int J Pediatr Otorhinolaryngol. 2002 Jan 11;62(1):53-7. doi: 10.1016/s0165-5876(01)00592-4.

Abstract

Hydroxychloroquine, a quinoline compound, rarely causes ototoxicity. According to the few reports in existence, hydroxychloroquine-induced ototoxicity occurred following prolonged therapy in adult patients with rheumatoid arthritis and lupus erythematosus. We report a case of unilateral sensorineural hearing loss in a 7-year-old girl with idiopathic pulmonary haemosiderosis, after 2 years of hydroxychloroquine treatment. Sensorineural hearing loss has previously been reported with hydroxychloroquine treatment, but this is the first report in a child and associated to idiopathic pulmonary haemosiderosis and has the characteristic of being unilateral.

摘要

羟氯喹啉是一种喹啉化合物,很少引起耳毒性。根据现有的少数报告,羟氯喹啉所致耳毒性发生于成年类风湿关节炎和红斑狼疮患者的长期治疗之后。我们报告一例7岁特发性肺含铁血黄素沉着症女童,在接受羟氯喹啉治疗2年后出现单侧感音神经性听力损失。此前曾有关于羟氯喹啉治疗导致感音神经性听力损失的报告,但这是首次在儿童中报告,且与特发性肺含铁血黄素沉着症相关,并且具有单侧性的特点。

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