Yovtcheva S P, Rifai M A, Moles J K, Van der Linden B J
Department of Psychiatry, University of Virginia/Roanoke-Salem Psychiatric Medicine Program, Salem, VA, USA.
Psychosomatics. 2001 Sep-Oct;42(5):411-5. doi: 10.1176/appi.psy.42.5.411.
This study assessed the prevalence of psychiatric disorders among hepatitis C patients at a Veterans Affairs Medical Center. Medical records of 306 randomly selected hepatitis C-positive patients were reviewed for past and present DSM-IV-based psychiatric disorders. Each psychiatric diagnosis was independently confirmed with DSM-IV criteria using symptoms recorded in the chart. Only independently confirmed diagnoses were included for analysis. Mood disorders were present in 38% of patients; personality disorders in 30%; PTSD in 19%; other anxiety disorders in 9%; and psychotic disorders in 17%. Although alcohol use disorders were found in 86% of this patient population, intravenous drug use disorders were present in only 28%. Our data indicate that prevalence rates of a variety of psychiatric disorders are higher in veterans with hepatitis C than in the general population. Mood, anxiety, personality, and psychotic disorders were all relatively common in these patients. Psychiatric disorders may influence the course and treatment of hepatitis C infection, and psychiatrists as well as internists should be aware of the substantial psychiatric comorbidity in patients with this infection.
本研究评估了一家退伍军人事务医疗中心丙型肝炎患者中精神障碍的患病率。回顾了306例随机选取的丙型肝炎阳性患者的病历，以确定过去和当前基于《精神疾病诊断与统计手册》第四版（DSM-IV）的精神障碍。使用病历中记录的症状，根据DSM-IV标准对每个精神诊断进行独立确认。仅纳入独立确认的诊断进行分析。38%的患者存在情绪障碍；30%存在人格障碍；19%存在创伤后应激障碍（PTSD）；9%存在其他焦虑障碍；17%存在精神障碍。尽管在该患者群体中86%发现有酒精使用障碍，但仅有28%存在静脉药物使用障碍。我们的数据表明，丙型肝炎退伍军人中各种精神障碍的患病率高于普通人群。情绪、焦虑、人格和精神障碍在这些患者中都相对常见。精神障碍可能会影响丙型肝炎感染的病程和治疗，精神科医生以及内科医生都应意识到这种感染患者中存在大量精神共病情况。
