Arnesen K, Nornes M
Acta Ophthalmol (Copenh). 1975 Mar;53(2):139-52. doi: 10.1111/j.1755-3768.1975.tb01148.x.
Ninety-five cases of malignant choroidal melanoma collected during a 15-year period have been studied with special emphasis on histological type, coexistence of benign nevus, and prognosis. Elements of benign nevus were found in 78% of the cases. The data tend to support the hyposis that most cases of malignant choroidal melanoma have their origin in a preexisting benign nevus, and that the tumours undergo a gradual change from a differentiated to a less differentiated type.
对15年间收集的95例脉络膜恶性黑色素瘤病例进行了研究，特别着重于组织学类型、良性痣的并存情况及预后。在78%的病例中发现了良性痣成分。这些数据倾向于支持这样的假说，即大多数脉络膜恶性黑色素瘤病例起源于先前存在的良性痣，并且肿瘤经历从分化型到低分化型的逐渐转变。
