Hingorani A, Ascher E, Kallakuri S, Greenberg S, Khanimov Y
Division of Vascular Surgery, Department of Surgery, Maimonides Medical Center, Brooklyn, New York 11219, USA.
J Vasc Surg. 2001 Dec;34(6):1004-9. doi: 10.1067/mva.2001.119750.
Although large published series have described their experience with the management of failed or failing prosthetic arteriovenous grafts for hemodialysis, there are scant data regarding failing arteriovenous fistulae (AVFs). To analyze the management of nonfunctioning or nonmaturing AVFs, we reviewed our experience with salvage procedures for these AVFs.
Of the 474 AVFs placed at our institution in 380 patients between June 1997 and March 2001, 75 revisions were performed in 46 patients (49 AVFs). Ages of these patients ranged from 29 to 94 years (mean, 68 +/- 1.4 years). Diabetic patients comprised 51%, and hypertensive patients comprised 75%. Twenty patients underwent 26 vein patch angioplasties, and 17 patients underwent 24 balloon angioplasties. Four patients required four vein interpositions, and 12 patients underwent 12 revisions of the fistula to a more proximal level. Extended salvage procedures consisted of four turn-downs to the basilic vein for proximal cephalic vein thrombosis or stenosis and five extension bypasses to the axillary or jugular vein for subclavian vein thrombosis.
Follow-up ranged from 1 to 31 months (mean, 10 months). The patients who underwent open revisions tended to need fewer subsequent procedures. However, primary patency of the vein patch angioplasty was not significantly better as compared with balloon angioplasty (P = .8) by life table analysis. Patency after revision of a radial cephalic fistula and brachial cephalic fistula were not statistically different. One interposition failed during the follow-up, and one revision to a more proximal level thrombosed during the follow-up. Two of the turn-down procedures had thrombosed at 2 and 11 months. The remaining two turn-down procedures have remained functional at 1 and 24 months. One of the extensions thrombosed at 8 months whereas the other four have remained functional at 1, 6, and 8 months.
Despite the limited follow-up data, this review suggests that simple and extended salvage procedures may allow maturation and add to the life span of AVFs for hemodialysis. In addition, these data suggest an advantage for open techniques as compared with percutaneous techniques but only in terms of requiring fewer subsequent procedures.
尽管大量已发表的系列研究描述了他们处理失败或即将失败的用于血液透析的人工动静脉移植物的经验,但关于即将失败的动静脉内瘘(AVF)的数据却很少。为了分析无功能或未成熟AVF的处理方法,我们回顾了我们对这些AVF进行挽救手术的经验。
1997年6月至2001年3月期间,我们机构为380例患者植入了474个AVF,其中46例患者(49个AVF)进行了75次修复手术。这些患者的年龄在29岁至94岁之间(平均68±1.4岁)。糖尿病患者占51%,高血压患者占75%。20例患者接受了26次静脉补片血管成形术,17例患者接受了24次球囊血管成形术。4例患者需要进行4次静脉间置术,12例患者将内瘘修复至更近端水平。扩大的挽救手术包括4次因头静脉近端血栓形成或狭窄而转向贵要静脉,以及5次因锁骨下静脉血栓形成而向腋静脉或颈静脉进行的延长搭桥术。
随访时间为1至31个月(平均10个月)。接受开放修复的患者后续往往需要较少的手术。然而,通过生存表分析,静脉补片血管成形术的初始通畅率与球囊血管成形术相比并无显著差异(P = 0.8)。桡动脉-头静脉内瘘和肱动脉-头静脉内瘘修复后的通畅率在统计学上无差异。1次间置术在随访期间失败,1次修复至更近端水平的手术在随访期间发生血栓形成。2次转向手术分别在2个月和11个月时发生血栓形成。其余2次转向手术在1个月和24个月时仍保持功能。1次延长搭桥术在8个月时发生血栓形成,而其他4次在1个月、6个月和8个月时仍保持功能。
尽管随访数据有限,但本综述表明,简单和扩大的挽救手术可能使AVF成熟并延长其用于血液透析的寿命。此外,这些数据表明与经皮技术相比,开放技术具有优势,但仅体现在后续需要的手术较少方面。