Warren B A, Khan S
Br J Exp Pathol. 1975 Aug;56(4):340-8.
The lysis of a fibrin clot by sheets of endothelium one cell thick was examined by scanning electron microscopy. The unlysed fibrin film appeared as a densely matted surface, without interstices. Commencing lysis appeared as parallel ovals in which the dense matting was altered to show many strands of fibrin criss-crossing the lytic "window" with many interstices. The wall of the lytic crater surrounding the sheets of endothelium revealed a network of fibrin strands. There was condensation of the fibrin at the edge of the hole at the external surface. The floor of the crater contained sheets of endothelium which were recognized by the shape and size of the nuclei. Flocculent masses of precipitate were present on the endothelial cells in the floor of the crater and occasionally within the lysed ovals at the edge. These may be fibrin degradation products.
通过扫描电子显微镜检查了由单层细胞厚的内皮细胞片对纤维蛋白凝块的溶解情况。未溶解的纤维蛋白膜呈现为致密交织的表面，没有间隙。开始溶解时呈现为平行的椭圆形，其中致密的交织结构发生改变，显示出许多纤维蛋白丝纵横交错地穿过有许多间隙的溶解“窗口”。围绕内皮细胞片的溶解坑壁显示出纤维蛋白丝网络。在外表面孔的边缘有纤维蛋白凝聚。坑底包含内皮细胞片，可通过细胞核的形状和大小识别。坑底的内皮细胞上以及偶尔在边缘溶解的椭圆形内存在絮状沉淀团块。这些可能是纤维蛋白降解产物。
