Warren B A, Khon S
Br J Exp Pathol. 1974 Apr;55(2):138-48.
The release of plasminogen activator from endothelial cells results in the lysis of fibrin-plasminogen clots. The ultrastructural morphology of this process was examined. Lysis occurred first over the cytoplasm of endothelial cells between the humps formed by the endothelial cell nuclei. The lytic region next became confluent and a condensed zone of fibrin (and possibly adsorbed products of lysis) was seen giving a distinct edge to the fibrin film. The endothelial cells remained relatively intact throughout the process, though there were indications of injury vesicular blebs were formed on the luminal surface of the endothelium. These were also seen attached to the edge of the fibrin. The edge of the lytic zone was characterized by small dense collections of fibrin fibrils which made a porous rim to the cleared area.
内皮细胞释放纤溶酶原激活物会导致纤维蛋白-纤溶酶原凝块溶解。对这一过程的超微结构形态进行了检查。溶解首先发生在内皮细胞核形成的隆起之间的内皮细胞胞质上。接下来，溶解区域融合，可见纤维蛋白（以及可能的溶解吸附产物）的浓缩区，使纤维蛋白膜有一个明显的边缘。在整个过程中，内皮细胞相对保持完整，不过有损伤的迹象——在内皮的管腔表面形成了水泡样小泡。这些小泡也附着在纤维蛋白边缘。溶解区的边缘以纤维蛋白原纤维的小致密聚集体为特征，这些聚集体为清除区域形成了一个多孔边缘。
