细胞周期蛋白D1过表达作为食管癌患者的一个预后因素。

Cyclin D1 overexpression as a prognostic factor in patients with esophageal carcinoma.

作者信息

Nagasawa S, Onda M, Sasajima K, Makino H, Yamashita K, Takubo K, Miyashita M

机构信息

Department of Surgery I, Nippon Medical School, Tokyo, Japan.

出版信息

J Surg Oncol. 2001 Nov;78(3):208-14. doi: 10.1002/jso.1152.

DOI:10.1002/jso.1152

PMID:11745809

Abstract

BACKGROUND AND OBJECTIVES

Cyclin D1 is known to play important roles in the G1/S check-point of the cell cycle. We investigated the correlation between cyclin D1 overexpression and clinical characteristics to clarify its prognostic significance in patients with esophageal cancer.

METHODS

From 1991 to 1998, cyclin D1 was investigated in esophageal cancers from 86 patients who underwent esophagectomy. Overexpression of cyclin D1 was demonstrated using an immunohistochemical method.

RESULTS

Overexpression of cyclin D1 was found in 23 (26.7%) of 86 cases. Overexpression of cyclin D1 correlated with lymph node metastasis (P = 0.0083) and lymphatic vessel invasion (P = 0.018). Cyclin D1 overexpression may indicate resistance to chemotherapy. The patients with cyclin D1 overexpression had a significantly lower survival rate than those without overexpression (P = 0.013). The multivariate analysis revealed cyclin D1 overexpression to be an important prognostic factor in patients with esophageal cancer.

CONCLUSIONS

Immunohistochemical examination of cyclin D1 expression may provide important prognostic information in univariate and multivariate analysis and may be necessary for determining therapeutic strategies for esophageal cancer.

摘要

背景与目的

已知细胞周期蛋白D1在细胞周期的G1/S检查点发挥重要作用。我们研究了细胞周期蛋白D1过表达与临床特征之间的相关性，以阐明其在食管癌患者中的预后意义。

方法

1991年至1998年，对86例行食管切除术的食管癌患者的肿瘤组织进行细胞周期蛋白D1检测。采用免疫组化方法检测细胞周期蛋白D1的过表达情况。

结果

86例患者中23例（26.7%）检测到细胞周期蛋白D1过表达。细胞周期蛋白D1过表达与淋巴结转移（P = 0.0083）及淋巴管浸润（P = 0.018）相关。细胞周期蛋白D1过表达可能提示对化疗耐药。细胞周期蛋白D1过表达患者的生存率显著低于未过表达患者（P = 0.013）。多因素分析显示，细胞周期蛋白D1过表达是食管癌患者重要的预后因素。