Djaldetti M, Ovadia J, Bessler O, Fishman P, Halbrecht I
Biol Neonate. 1975;26(5-6):367-74. doi: 10.1159/000240751.
The ultrastructural features of the erythropoietic events in 5- to 9-week embryonic livers are described. By the 5th week of gestation, the human embryonic liver becomes an active site of erythropoiesis represented by the formation of reticular-mesenchyme cells and hemocytoblasts. At the 6--7th week, the first proerythroblasts and islands of polychromatophilic and orthochromatic erythroblasts can be detected. From this stage, by the 8th week of embryonic development, the liver assumes its function as a fully developed embryonic organ. In the embryonic livers studied there were no signs of granuloor lymphopoiesis. Although megakaryocytes were found in the 8-week embryonic liver, there is no evidence that these cells are produced in the liver. Macrophages were found in the 5-week embryonic liver.
描述了5至9周龄胚胎肝脏中红细胞生成事件的超微结构特征。在妊娠第5周时，人类胚胎肝脏成为红细胞生成的活跃部位，表现为网状间充质细胞和成血细胞的形成。在第6至7周时，可检测到第一批早幼红细胞以及多染性和正染性成红细胞岛。从这个阶段开始，到胚胎发育第8周时，肝脏发挥其作为完全发育的胚胎器官的功能。在所研究的胚胎肝脏中，没有粒细胞或淋巴细胞生成的迹象。尽管在8周龄胚胎肝脏中发现了巨核细胞，但没有证据表明这些细胞是在肝脏中产生的。在5周龄胚胎肝脏中发现了巨噬细胞。
