Sybulski S, Maughan G B
Biol Neonate. 1975;27(5-6):302-7. doi: 10.1159/000240787.
The average estradiol concentrations in umbilical cord plasma from newborns which developed respiratory distress with or without hyaline membrane disease (RDS) were lower by 25% than in controls. Complication of pregnancy by maternal diabetes or pruritus has been associated with abnormalities in estrogen concentrations in the mother, but cord plasma estradiol levels in these cases were essentially normal. Because of reports that treatment of the mother before delivery with estrogens or glucocorticoids results in a decreased incidence of RDS in newborns the relationship between endogenous estradiol and cortisol levels in cord plasm was investigated. There was no significant correlation between the concentrations of these steroids in 65 specimens; the cortisol levels associated with two cases of severe RDS were low.
患有或未患有透明膜病（RDS）的新生儿发生呼吸窘迫时，其脐带血血浆中的平均雌二醇浓度比对照组低25%。母亲患糖尿病或瘙痒症等妊娠并发症与母亲体内雌激素浓度异常有关，但这些情况下的脐带血血浆雌二醇水平基本正常。由于有报道称，分娩前给母亲使用雌激素或糖皮质激素可降低新生儿RDS的发生率，因此对脐带血中内源性雌二醇和皮质醇水平之间的关系进行了研究。65份样本中这些类固醇的浓度之间无显著相关性；与两例严重RDS相关的皮质醇水平较低。
